- Original Article
- Protective Effect of Probucol against Adriamycin-Induced Apoptosis in Cultured Rat Cardiac Myocytes
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Sun-Ju Lee, Dong-Seok Lee, Yong-Wook Jung
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Clin Exp Pediatr. 2000;43(6):746-754. Published online June 15, 2000
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Purpose : In adriamycin(ADR)-induced cardiomyopathy, several different mechanisms are suggested. However, little information is available regarding the role of apoptosis. In the present study, we examined the induction of apoptosis on ADR treatment and anti-apoptotic effects of probucol, a lipid-lowering drug, and we also studied the changes of bcl-2 expression in order to see the molecular mechanisms underlying the effect... |
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